MHH DISSERTATION 2012

Cardiac expression of its bioinformatically predicted target mimecan osteoglycin, OGN was gradually decreased with advanced age. For all details of the program, see www. Histological damage in the outer medulla is significantly reduced by miR silencing in vivo. Blocking of endothelial miR limited myocardial infarct size of mice via prevention of endothelial apoptosis and enhancement of vascularity, which led to preserved cardiac function and survival. Thum for his outstanding contributions to cardiovascular research. This was observed by researchers about three years ago.

May We identified miR in the heart to be regulated by osteopontin OPN , an important pro-fibrotic cytokine. Overall, these results indicate miR promotes renal ischemic injury by stimulating apoptosis in endothelial and tubular epithelial cell. Thomas Thum entitled “Quaking inhibits Doxorubicin-mediated cardiotoxicity through regulation of cardiac circular RNA expression” published in Circulation Research was selected for the award. He and his team will use the new funding of 1. September New therapies for conditions such as cardiac hypertrophy and heart failure are needed and may be developed as a result of a better understanding of the tight regulation of gene transcription in heart muscle cells. Histological damage in the outer medulla is significantly reduced by miR silencing in vivo.

The award was presented to Dr.

Circulating miRNAs are remarkably stable in the blood. Thomas Thum aims to identify novel therapies disseetation cardiovascular diseases based on non-coding RNA molecules. Despite the preliminary character of the promising initial data, the results provide rationale for a confirmation study in larger MS cohorts.

This achievement highlights the importance of her research focused at the investigation of Telomerase mediated cardioprotection.

202 He aims to develop and test microRNA based therapies in small and large animal models of myocardial infarction and congestive heart failure. Thum for his outstanding contributions to cardiovascular research. September Autophagy is a self-renewal process and in a non-dividing cell like cardiomyocytes, it is very important to maintain the cellular homeostasis. MicroRNAbased therapeutic treatment of myocardial infarction.

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Insufficient myocardial capillary density after MI has been identified as a critical event in the remodelling process that can be targeted with novel therapeutic strategies. Gupta and colleagues screened for microRNAs regulating cardiac autophagy and will use the stipendium to study selected microRNA candidates.

What is the molecular difference between newborn and adult hearts? Ankita presented her work characterising mineralocorticoid receptor induced cardiac remodeling, whilst Michael introduced his PhD project on the role of circRNAs in hypertrophic cardiomyopathy induced heart failure.

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Outstanding Achievement Award to Prof. Sandor Batkai cissertation co-hosted by Prof. In cardiovascular disease the diagnostic utility of circulating lncRNAs has not been investigated so far.

April Physiological aging and senescence are associated to progressive decline in most physiological functions, reduced response to stress, loss of viability and increased susceptibility to various diseases. Preliminary data about the abundance of miRNAs in platelets suggests that a distinct miRNA network may regulate the platelet gene expression.

Dissrtation interference RNA-mediated silencing of mimecan in cardiac fibroblasts mimicked the miRmediated effects. Inhibition of miR post myocardial infarction in aging mice improves cardiac function and inhibits cardiac remodeling. Platelets play an important role in general hemostasis maintenance and pathophysiology of thrombosis. The scientific aim is to develop new diagnosis possibilities and therapies for disserfation diseases, which are based on microRNAs.

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Overexpression of this transcript induced pathological heart growth, while antisense-oligonucleotide mediated blockage of the lncRNAs activity prevented and attenuated hypertrophic cardiac remodeling, opening new avenues for therapeutical applications and strategies. Our group now identified that the small noncoding RNA microRNA miR is enriched in cardiac endothelial cells and considerably upregulated after cardiac ischemia.

This was observed by researchers about three years ago.

mhh dissertation 2012

The European researchers will firstly identify biomarker candidates in blood and study their predictive value for heart failure and common co-morbidities associated with ageing renal impairment, cognitive disorders….

Details can be found at: And we can even only dream of a remarkable capacity dissertaation newborns have: Sandor Batkai was awarded a three year Marie Curie Grant by the European Commission to support his professional reintegration to Germany.

MHH researchers launching French-German network for improved therapy after myocardial infarction.

mhh dissertation 2012

The JPM program is meant to give a tool box for the phase of transition to leadership position and the increasing amount of scientific management duties. Autophagy is a catabolic process where the cell renews 20112 damaged organelles and non-functional proteins.

mhh dissertation 2012

Thum joins Imperial College London as visiting professor. Inhibition of Chast in mice by molecules counteracting its activity prevented and attenuated the abnormal growth of the heart and improved the pump function.

The idea is that also the adult heart would regenerate if the correct switches are pushed.